selective inhibition — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5722	Nevadensin	Pedunculin	Anti-infection , Antibacterial
	Nevadensin is an important herb-based constituent inhibiting estragole bioactivation. Nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat. It also exhibits inhibition acti...		Anti-infection , Antibacterial
T60080	TMPH	2,2,6,6-Tetramethylpiperidin-4-yl heptanoate	AChR
	TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.		AChR
T2051	SKLB4771	FLT3-IN-1,FLT3-IN-1	FLT
	SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.		FLT
T12430	PF-06821497		Histone Methyltransferase
	PF-06821497 is a selective inhibitor of EZH2 with significant tumor growth inhibition.		Histone Methyltransferase
TN2202	Sempervirine		DNA/RNA Synthesis
	Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA .		DNA/RNA Synthesis
T24444	Medifoxamine	LG 152,Medifoxamina,LG-152,LG152	Dopamine Receptor , Monoamine Oxidase
	Medifoxamine (LG 152) is a selective non-monoamine oxidase inhibitor that exhibits antidepressant activity through inhibition of 5 HT reuptake.Medifoxamine preferentially inhibits dopamine reuptake.		Dopamine Receptor , Monoamine Oxidase
T9015	LY900009		Gamma-secretase
	LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.		Gamma-secretase
T2267	BQU57		GTPase , Ras
	BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.		GTPase , Ras
T6546	IPA-3	IPA3,IPA 3	PAK
	IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).		PAK
T8187	Tetrahydroepiberberine		Others , Influenza Virus , Antifungal
	Tetrahydroepiberberine, an isoquinoline alkaloid, has antifungal and selective inhibition against the PI-3 virus activities.		Others , Influenza Virus , Antifungal
T5455	HT-2157	SNAP37889,SNAP-37889	Neuropeptide Y Receptor
	HT-2157 (SNAP-37889) is a selective, high-affinity competitive antagonist of the galanin-3 receptor (Gal3), demonstrating effective inhibition of this target.		Neuropeptide Y Receptor
T6481	Droxinostat	NS 41080	Apoptosis , HDAC
	Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.		Apoptosis , HDAC
T6008	CNX-2006	CNX 2006,CNX2006	EGFR
	CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.		EGFR
T2458	CID755673		Serine/threonin kinase
	CID755673 is an effective and specific cell-active inhibitor for PKD (IC50: 182 nM); exhibits selective PKD1 inhibition when compared with PLK1, AKT, CAMKIIα, CAK, and PKC isoforms.		Serine/threonin kinase
T5405	BI-1347		CDK
	BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.		CDK
T41160	Lalistat 2		Lipase
	Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC50 of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).		Lipase
T27172	Difamilast		PDE
	Difamilast is an inhibitor of phosphodiesterase IV.		PDE
T6175	ADL-5859	ADL5859 Hydrochloride,ADL5859 HCl	Opioid Receptor
	ADL-5859 (ADL5859 Hydrochloride) is a selective δ-opioid receptor agonist ( Ki: 0.8 nM), selectivity against opioid receptor κ, μ, and little inhibition for the hERG channel.		Opioid Receptor
T15558	GSK319347A		IκB/IKK
	GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma.		IκB/IKK
T6296	RAF265	CHIR-265	Apoptosis , Raf , VEGFR , Autophagy
	RAF265 (CHIR-265) (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM. Phase 2.		Apoptosis , Raf , VEGFR , Autophagy